Dietary Selenium-Rich Lactobacillus plantarum Alleviates Cadmium-Induced Oxidative Stress and Inflammation in Bulatmai barbel Luciobarbus capito

Cadmium (Cd) poses a great threat to the breeding of aquatic economic animals. The present study aimed explain antagonistic effects selenium-enriched Lactobacillus plantarum (SL) on Cd toxicity through expression oxidative and inflammatory factors. A total 225 Bulatmai barbel Luciobarbus capito (L. capito) were divided into 3 groups, namely, control group, group (Cd, 0.05 mg·L−1), SL + mg·L−1; Nano Se, 5 mg·kg−1; L. plantarum, 105 CFU·g−1). experiment lasted for 28 d, Sampling at 14 respectively. results showed that exposure caused obvious pathological damage liver kidney, serum parameter ALT increased significantly (p < 0.05). In concentration in kidney was 0.05), activities catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) gill decreased; malonaldehyde (MDA) 0.05) Then mRNA levels measured. decreased expressions SOD, CAT, GSH-Px, HO-1, I-κBα, Nrf2 Cd-treated NF-kBp65, TGF-β, IL-8, IL-1, Keap1, TNF-α levels. alleviated changes above indicators. this suggest can trigger signalling pathway NF-kB alleviate toxicity. might be potential drug treatment poisoning.